Truly Personalized Medicine is Here It’s far more important to know what person the disease has than what disease the person has. – Hippocrates

Truly Personalized Medicine is Here It’s far more important to know what person the disease has than what disease the person has. – HippocratesThe concept of personalized medicine – tailoring the treatment to the individual – has been around for more than 2,000 years.

It hasn’t been until recently, however, that the promise of personalized medicine has become reality. The mapping of the human genome has allowed us to understand the impact of genes, and their variants, on the metabolism of medications. Advances in computer technology have allowed us to gather data and analyze it, leading to a more complete understanding of disease. Developments in laboratory science allow us to develop medications, such as specific treatments for cystic fibrosis and cancers, that target specific genetic changes.

Personalized medicine is more than just “the next big thing.” It is the future of medicine,
benefiting the patient, the family, the clinician, the community and the world. The promise of personalized medicine is powerful:

• Now, clinicians can offer more confidence and certainty in choosing medications to treat a specific condition. Medication trial (and error) will soon be a thing of the past for a wide array of conditions.

• Patients don’t waste valuable time and money on medications that won’t work.

• Families will no longer have to worry about mom or child, dad or sister and whether this round of medications will work.

• Employers and the community at large benefit because patients get well more quickly, with less cost, reducing lost time and wasted healthcare dollars.

The technology that makes it possible – PGx testing – is available today, in Lexington, at Lexar Labs. Lexar Labs specializes in supporting physicians, clinics, treatment facilities and
hospitals in providing personalized medical treatment to the patient.

Getting started is easy. For most patients, all that is required is a simple and rapid saliva test. The collected DNA is analyzed by Lexar Labs and a comprehensive report provided to the clinician to help guide treatment decisions.

The PGx report includes recommendations on medications most likely to work, as well as cautions against medications that testing indicates may cause severe reactions or have no effect at all. PGx testing allows the clinician to personalize treatment plans for patients by having specific knowledge of the patient’s medication metabolism. It allows the clinician to tailor the correct medications and doses, thus decreasing adverse side effects and drug or food interactions.

How it works
Many patients have a gene variant that affects the function of one or more drug metabolizing enzymes—the cytochrome P450 enzymes. pathways.  There are more than 50 cytochrome P450 enzymes, but just a handful of those enzymes control the metabolism of approximately 80 percent of prescription medications available today.

All enzymes, including enzymes in the cytochrome P450 family, are produced by specific genes. Gene variants can lead to a change in the amount of enzyme produced in the liver, which leads to variations in the individual’s ability to metabolize medications. These variations in metabolism may contribute to toxicity in one patient and reduced effectiveness in another. The effectiveness of medication can also be altered by variants in pharmacodynamic genes. Informed PGx analyzes variants in both the pharmacokinetic and pharmacodynamic pathways.

Find out more
If providing truly personalized medicine to your patients is important to you, Lexar Labs can help. For more information, please call Lexar Labs at (859) 543-2202. A Lexar Labs representative will be happy to answer your questions and discuss how we can help you provide truly individualized care to your patients.

If you’re a patient who is interested in learning more, please visit our website at lexarlabs.com or speak to your physician about whether pharmacogenomics testing might be beneficial to you in enhancing your medication treatment.

Lexar Labs is a full service laboratory located at 3221 Summit Square, Suite 100-150,
Lexington, Ky. Lexar Labs can be reached at (859) 543-2202 or email info@lexarlabs.com.

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